Seema Thakral

Seema Thakral headshot

Seema Thakral

Communications Director, Scientist


Shepherd Labs
Room 14
100 Union St SE
Minneapolis, MN 55455
  • Ph.D. (Pharmaceutical Sciences), Masters in Pharmacy (Pharmaceutics), Bachelor in Pharmacy, Delhi University, India
Selected Publications
  1. Thakral S*, Kim K, 2020. Small-angle scattering for characterization of pharmaceutical materials. Trends in Analytical Chemistry. Accepted for publication.
  2. Bermel EA, Thakral S, Claeson AA, Ellingson AM, Barocas VH, 2020. Asymmetric in-plane shear behavior of isolated cadaveric lumbar facet capsular ligaments: Implications for subject specific biomechanical models. Journal of Biomechanics. 2020, 105, 109814.
  3. Thakral S, Sonje J, Suryanarayanan R, 2020. Anomalous behavior of mannitol hemihydrate: Implications on sucrose crystallization in colyophilized systems. International Journal of Pharmaceutics 587, 119629.
  4. Sonje J, Thakral S, Suryanarayanan R, 2020. t-Butanol enables dual functionality of mannitol: a cryoprotectant in frozen systems and bulking agent in freeze-dried formulations. Molecular Pharmaceutics 17 (8), 3075-3086.
  5. Kaur N, Duggirala NK, Thakral S, Suryanarayanan R, 2020. Role of lattice disorder in water-mediated dissociation of pharmaceutical cocrystal systems. Molecular Pharmaceutics 16 (7), 3167-3177.
  6. Thakral S*, Garcia-Barriocanal J, Thakral NK. 2019. Effect of processing conditions and excipients on dehydration kinetics of sodium naproxen hydrate in formulation. International Journal of Pharmaceutics, 557, 221-228.
  7. Thakral NK. Thakral S, Stephenson GA, Sedlock R, Suryanarayanan, R. 2019. Compression induced polymorphic transformation in tablets: Role of shear stress and development of mitigation strategies. Journal of Pharmaceutical Sciences, 108, 476-484.
  8. Thakral NK, Zanon RL, Kelly RC, Thakral S*. 2018. Applications of powder X-ray diffraction in small molecule pharmaceuticals: achievements and aspirations. Journal of Pharmaceutical Sciences, available online. Selected as Feature article for virtual issue and regarded as “particularly original and significant”.
  9. Wolf A, Thakral S, Beilman GJ, Suryanarayananan R. 2018. Evaluation of novel formulations of d-β-hydroxybutyrate and melatonin in a rat model of hemorrhagic shock. International Journal of Pharmaceutics, 548, 104.
  10. Thakral S, Koranne S, Suryanarayanan R. 2018. Intra-vial heterogeneity in physical form of mannitol in colyophilized binary systems. Pharmaceutical Research, 35, 214.
  11. Koranne S, Thakral S, Suryanarayanan R. 2018. Effect of formulation and process parameters on the disproportionation of indomethacin sodium in lyophilized formulations. Pharmaceutical Research, 35, 21.
  12. Thakral S, Thakral NK, Suryanarayanan R. 2018. Estimation of drug particle size in intact tablet by two-dimensional X-ray diffractometry. Journal of Pharmaceutical Sciences. 107 (1), 231-238.
  13. Thakral S, Wolf A, Beilman GJ, Suryanarayananan R. 2017. Development and in vivo evaluation of a novel lyophilized formulation for the treatment of hemorrhagic shock. International Journal of Pharmaceutics, 537, 162-171.
  14. Thakral S, Terban MW, Thakral NK, Suryanarayanan R. 2016. Recent advances in the characterization of amorphous pharmaceuticals by X-ray diffractometry. Advanced Drug Delivery Reviews 100, 183-93.
  15. Thakral S, Suryanarayanan R. 2015. Salt formation during freeze-drying - an approach to enhance indomethacin dissolution. Pharmaceutical Research 32, 3722-31.
  16. Bansal K, Baghel US, Thakral S*. 2015. Construction and Validation of Binary Phase Diagram for Amorphous Solid Dispersion Using Flory-Huggins Theory. AAPS PharmSciTech 1-10.
  17. Thakral S*. 2014. Study of moisture sorption behavior of urea inclusion compounds with aliphatic guests and with linear polymers. Journal of Physical Organic Chemistry 27, 76-86.
  18. Thakral S, Thakral NK, Majumdar DK. 2013. Eudragit: A technology evaluation. Expert Opinion in Drug Delivery 10, 131-49.
  19. Thakral S*, Thakral NK. 2013. Prediction of drug-polymer miscibility through the use of solubility parameter based Flory-Huggins interaction parameter and the experimental validation: PEG as model polymer. Journal of Pharmaceutical Science 102, 2254-63.
  20. Arora KD, Thakral S, Suryanarayanan R. 2013. Instability in theophylline and carbamazepine hydrate tablets: Cocrystal formation due to release of lattice water. Pharmaceutical Research 30, 1779-89.
  21. Thakral S, Madan AK. 2008. Reduction in moisture sensitivity/ uptake of moisture sensitive drugs through adduction in urea. Journal of Pharmaceutical Innovation 3, 249-57.
  22. Thakral S, Madan AK. 2008. Urea co-inclusion compounds of 13-cis retinoic acid for simultaneous improvement of dissolution profile, photostability and safe handling characteristics. Journal of Pharmacy and Pharmacology 60, 823 900.
  23. Thakral S, Madan AK. 2008. Adduction of amiloride hydrochloride in urea through a modified technique for the dissolution enhancement. Journal of Pharmaceutical Sciences 97, 1191-202.
  24. Thakral S, Madan AK. 2007. Urea inclusion compounds of enalapril maleate for improvement of pharmaceutical characteristics. Journal of Pharmacy and Pharmacology 59, 1501-7.
  25. Thakral S*, Mehta RM. 2006. Fullerenes: An introduction and overview of their biological properties. Indian Journal of Pharmaceutical Sciences 68, 13-9.
  26. Mendiratta S, Madan AK. 1994. Structure activity study on antiviral 5- vinyl pyrimidine nucleoside analogs using Wiener topological index. Journal of Chemical Information and Computer Sciences 34, 867-71.


  1. Thakral S, Govindrajan R, Suryanarayanan R, 2018. Processing-induced phase transformations and their implications on pharmaceutical product quality. In Polymorphism in the Pharmaceutical Industry: Solid Form and Drug Development, Edition 2. Hilfiker R, von Raumer M, Wiley-VCH.
  2. Thakral S*, Thakral NK, 2012. Potential medical applications of Fullerenes: An overview. In Bionanotechnology: A Revolution in Biomedical Sciences & Human Health. Bagchi D, Moriyama H, John Wiley & Sons, Chapter 24.
  3. Thakral S, Madan AK, 2009. Urea as an adductor for branched drug molecules. In Macrocyclic Chemistry: New Research Developments. Fitzpatrick DW, Ulrich HJ, Nova Science Publishers. ISSN # 978-1-61209-255-3. Chapter 18.