Environmental robustness of the global yeast genetic interaction network [journal]

Journal

Science - May 7, 2021

Authors

Michael Costanzo, Jing Hou, Vincent Messier, Justin Nelson (M.S. student), Mahfuzur Rahman (Ph.D. student), Benjamin VanderSluis (researcher), Wen Wang (researcher), Carles Pons, Catherine Ross, Matej Ušaj, Bryan-Joseph San Luis, Emira Shuteriqi, Elizabeth N. Koch (Ph.D. student), Patrick Aloy, Chad L. Myers (professor), Charles Boone, Brenda Andrews

Abstract

Phenotypes associated with genetic variants can be altered by interactions with other genetic variants (GxG), with the environment (GxE), or both (GxGxE). Yeast genetic interactions have been mapped on a global scale, but the environmental influence on the plasticity of genetic networks has not been examined systematically. To assess environmental rewiring of genetic networks, we examined 14 diverse conditions and scored 30,000 functionally representative yeast gene pairs for dynamic, differential interactions. Different conditions revealed novel differential interactions, which often uncovered functional connections between distantly related gene pairs. However, the majority of observed genetic interactions remained unchanged in different conditions, suggesting that the global yeast genetic interaction network is robust to environmental perturbation and captures the fundamental functional architecture of a eukaryotic cell.

Link to full paper

Environmental robustness of the global yeast genetic interaction network

Keywords

bioinformatics, computational biology