New Publication on Isolation of Chemoresistant Cancer Cell Populations
Illustration of ovarian cancer cell encapsulation

ME Professor Alptekin Aksan has a new paper on isolation of chemoresistant cancer cell populations using physical inhibition of proliferation. The research was led by Professor Samira Azarin and graduate student Tiffany Lam and was published in Biotechnology and Bioengineering.

"We encapsulated ovarian cancer cells in stiff, porous silica gels, where cells become immobilized and growth-inhibited," said Aksan. "We showed that the cells which survive immobilization exhibited an enhanced ability to enter dormancy and were more chemoresistant to multiple types of drugs."

The multidisciplinary team includes:

Samira M. Azarin — UMN Department of Chemical Engineering and Materials Science
Tiffany Lam — UMN Department of Chemical Engineering and Materials Science
Julio A. Aguirre-Ghiso — Icahn School of Medicine
Melissa A. Geller — UMN Department of Obstetrics, Gynecology, and Women's Health
 

Read the full paper here:

"Immobilization rapidly selects for chemoresistant ovarion cancer cells with enhanced ability to enter dormancy"

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