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Publications

 

Journal Articles

  1. Win Z, Buksa JM, Alford PW. Architecture-dependent anisotropic hysteresis in smooth muscle cells. Biophys J. 2018; 115(10), 2044-2054
  2. Tabdanov ED, Puram V, Win Z, Alamgir A, Alford PW, Provenzano PP. Biomodal sensing of guidance cues in mechanically complex microenvironments. Nat Comm. 2018. 9(1), 4891
  3. Wheelwright M, Win Z, Mikkila JL, Amen KY, Alford PW, Metzger JM. Investigation of human iPSC-derived cardiac myocyte functional maturation by single cell traction force microscopy. PLoS One 13(4) e0194909
  4. Steucke KE, Win Z, Walsh EE, Stemler TR, Alford PW. Direct measurement of vascular smooth muscle cell mechano-adaptation laws. J Biomech Eng 2017; 139(7) 071005
  5. Win Z, Buksa JM, Luxton GWG, Barocas VH, Alford PW. Cellular Microbiaxial Stretching to Measure a Single-Cell Strain Energy Density Function. J Biomech Eng 2017;  139(7) 071006
  6. Ray A, Lee O, Win Z, Edwards RM, Alford PW, Kim DH, Provenzano PP. Anisotropic forces from spatially constrained focal adhesions mediate contact guidance directed cell migration. Nat Comm. 2017; 8, 14923
  7. Witzenberg CM, Dhume RY, Shah SB, Korenczuk CE, Wagner HP, Alford PW, Barocas VH. Failure of the Porcine Ascending Aorta: Multidirectional Experiments and a Unifying Microstructural Model. J Biomech Eng. 2017; 139(3) 031005
  8. van Loosdregt IAEW, Dekker S, Alford PW, Oomens CWJ, Loerakker S, Bouten CVC. Cellular stress generation is independent of organization in tissue engineered cell sheets. Cardiovasc Eng Tech. 2016. doi:10.1007/s13239-016-0283-9
  9. Hald ES, Timm CD, Alford PW. Amyloid beta influences vascular smooth muscle contractility and mechano-adaptation. J Biomech Eng. 2016; 138(11): 111007 doi:10.1115/1.4034560
  10. Steucke KE, Tracy PV, Hald ES, Hall JL, Alford PW. Vascular smooth muscle cell functional contractility depends on extracellular mechanical properties. J Biomech. 2015; 48 (12) 3044-3051.
  11. Lee H, Adams WJ, Alford PW, McCain ML, Feinberg AW, Sheehy SP, Goss JA, Parker KK. Cytoskeletal prestress regulates nuclear shape and stiffness in cardiac myocytes. Exp Biol Med. 2015 0; 1-12 DOI: 10.1177/1535370215583799.
  12. Adhikari N, Shekar KC, Staggs R, Win Z, Steucke KE,  Lin YW, Wei LN, Alford PW, Hall JW Guidelines for the Isolation, Culturing and Characterization of Murine Vascular Smooth Muscle Cells. J of Cardiovasc Trans Res. 2015 8 (3), 158-163.
  13. Hald ES, Steucke KE, Reeves JA, Win Z, Alford PW. Microfluidic genipin deposition technique for extended culture of micropatterned vascular muscular thin films. JoVE 2015; e52971-e52971.
  14. Smith AM, Stuart MJ, Dodick DW, Roberts WO, Alford PW, et al. Ice Hockey Summit II: Zero Tolerance for Head Hits and Fighting. PM&R. 2015; 25 (2), 78-87.
  15. Win Z, Vrla GD, Steucke KE, Sevcik EN, Hald ES, Alford PW. Smooth muscle architecture within cell-dense vascular tissue influences functional contractility. Integr Biol. 2014; 6 (12),
  16. Hald ES, Steucke KE, Reeves JA, Win Z, Alford PW. Long-term vascular contractility assay using genipin-modified muscular thin films. Biofabrication. 2014 6(4): 045005.
  17. Hald ES, Alford PW. Smooth Muscle Phenotype Switching in Blast Traumatic Brain Injury-Induced Cerebral Vasospasm. Trans Stroke Res. 2014 5:385-393 (Review)
  18. Shah SB, Witzenburg C, Hadi MF, Wagner HP, Goodrich JM, Alford PW, Barocas VH. Prefailure and Failure Mechanics of the Porcine Ascending Thoracic Aorta: Experiments in a Multiscale Model. J Biomech Eng. J Biomech Eng. 2014; 136(2), 021028.
  19. Ye GJC, Aratyn-Schaus Y, Nesmith AP, Pasqualini FS, Alford PW, Parker KK .The contractile strength of vascular smooth muscle myocytes is shape dependent Integr Biol. 2014; 6: 152-163.
  20. Feinberg AW, Alford PW, Jin H, Ripplinger CM, Sheehy SP, Werdich A, Parker KK. Contolling the Contractile Strength of Engineered Cardiac Muscle by Hierarchal Tissue Architecture. Biomaterials. 2012; 33(23), 5732-5741.
  21. Grosberg A, Alford PW, McCain ML, Parker KK. Measuring Structure-Function Relationships in Multiple Cardiac Tissues Simultaneously: Heart on a Chip Technology for Drug Discovery and Safety. Lab Chip. 2011; 11(24), 4165-4173.
  22. Balachandran KB, Alford PW, Wylie-Sears J, Goss JA, Grosberg A, Bischoff J, Aikawa E, Levine R, Parker KK. Cyclic Strain Induces Dual-Mode Endothelial-Mesenchymal Transformation of the Cardiac Valve. Proc Nat Acad Sci. 2011; 108(50) 19943-19948.
  23. Alford PW, Nesmith AP, Seywerd JN, Grosberg A, Parker KK. Smooth Muscle Contractility Depends on Cell Shape. Integr. Biol. 2011; 3(11), 1063-1070.
  24. Alford PW, Dabiri BE, Goss JA, Brigham MD, Hemphill MA, Parker KK. Blast-Induced Phenotypic Switching in Cerebral Vasospasm. Proc Nat Acad Sci. 2011; 108 (31) 12705-12710.
  25. Hemphill MA, Dabiri BE, Gabriele S, Kerscher L, Franck C, Goss JA, Alford PW, Parker KK. A Possible Role for Integrin Signaling in Diffuse Axonal Injury. PLoS One; 2011; 6:e22899.
  26. Alford PW*, Feinberg AW*, Sheehy SP, Parker KK. Biohybrid Thin Films for Measuring Contractility in Engineered Cardiovascular Muscle. Biomaterials. 2010; 31: 3613-3621. (* contributed equally)
  27. Alford PW, Taber LA. Computational study of growth and remodelling in the aortic arch. Comput Methods Biomech Biomed Engin. 2008;11:525-38.
  28. Alford PW, Humphrey JD, Taber LA. Growth and remodeling in a thick-walled artery model: effects of spatial variations in wall constituents. Biomech Model Mechanobiol. 2008;7:245-62.
  29. Voronov DA, Alford PW, Xu G, Taber LA. The role of mechanical forces in dextral rotation during cardiac looping in the chick embryo. Dev Biol. 2004;272:339-50.
  30. Alford PW, Taber LA. Regional epicardial strain in the embryonic chick heart during the early looping stages. J Biomech. 2003;36:1135-41.

 

Book Chapters

  1. Alford PW. Elasticity-Based Targeted Growth Models of Morphogenesis. Methods in Molecular Biology Tissue Morphogenesis. 2015. Humana Press, NY, NY (ed. CM Nelson)