• Molecular mechanisms of damage during freezing
• Mechanisms of cryoprotection or cryoinjury
• Low temperature imaging of biological systems
• Preservation of cells and tissues
• Microfluidics and transport in microfluidic channels

Allison Hubel combines her interest in heat and mass transfer, material science and biology to address issues related to preservation of cells and tissues for therapeutic applications.  She uses imaging techniques to detect cell response to freezing, optimization algorithms to improve preservation outcome and a variety of other tools to understand the behavior of water during freezing and molecular mechanisms of protection.  

Lab
BioCor - Biopreservation Core Research - ME 3134
Hubel Research Group

ME Research Areas
Biosystems & Bioengineering
Thermodynamics & Heat Transfer

ME Impact Areas
Human Health
Next-Gen Manufacturing

Education

Ph.D. 1989, Mechanical Engineering, Massachusetts Institute of Technology
M.S. 1989, Mechanical Engineering, Massachusetts Institute of Technology
B.S. 1983 Mechanical Engineering, Iowa State UniversitySociety for Cryobiology

Scientific & Professional Societies

Teaching Subjects

• ME 3331: Thermal Sciences I
• ME 3333: Thermal Sciences III
• ME 4031: Basic Mechanical Measurements Laboratory
• ME 4331: Thermal Energy Engineering Laboratory
• ME 5666: Modern Thermodynamics

Honors and Awards

• 2017 Outstanding Achievement in Biobanking, ISBER
• 2013 Scholar, National Blood Foundation
• 2012 Fellow, American Institute of Medical and Biological Engineers
• 2008 Fellow, American Society of Mechanical Engineers
• 2001 Presidential Distinguished Faculty

Selected Publications

• Pi CH, Dosa PI, Hubel A, “Differential evolution for the optimization of the DMSO-free cryoprotectants:  influences of control parameters, J Biomech Engr, 142 (7):  071006.
• Li R, Hornberger K, Dutton JR, Hubel A, “Cryopreservation of human iPS cell aggregates in a DMSO-free solution-an optimization and comparative study”, Frontiers in Biotechnology, DOI: 10.3389/fbioe.2020.00001.
• Pi CH*, Hornberger K*, Dosa PI, Hubel A, "Understanding the frreezing responses of T-cells and other subsets of human peripheral blood mononuclear cells using DSMO-free cryoprotectants, Cytotherapy," 22(5): 291-300, 2020.
• Hornberger K, Li R, Duarte ARC, Hubel A, “Natural Deep Eutectic systems for nature-inspired preservation of cells”, AICHE J, DOI: 10.1002/aic.17085.
• Li R, Johnson R, Yu G, McKenna DH, Hubel A, “Preservation of cell-based immunotherapies for clinical trials”, Cytotherapy, 21(9): 943-957, 2019.

More Publications

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