Ph.D. 1989, Mechanical Engineering, Massachusetts Institute of Technology
M.S. 1989, Mechanical Engineering, Massachusetts Institute of Technology
B.S. 1983 Mechanical Engineering, Iowa State University
Allison Hubel combines her interest in heat and mass transfer, material science and biology to address issues related to preservation of cells and tissues for therapeutic applications. She uses imaging techniques to detect cell response to freezing, optimization algorithms to improve preservation outcome and a variety of other tools to understand the behavior of water during freezing and molecular mechanisms of protection.
Lab
BioCor - Biopreservation Core Research - ME 3134
Hubel Research Group
ME Research Areas
Biosystems & Bioengineering
Thermodynamics & Heat Transfer
ME Impact Areas
Human Health
Next-Gen Manufacturing
Pi CH, Dosa PI, Hubel A, “Differential evolution for the optimization of the DMSO-free cryoprotectants: influences of control parameters, J Biomech Engr, 142 (7): 071006.
Li R, Hornberger K, Dutton JR, Hubel A, “Cryopreservation of human iPS cell aggregates in a DMSO-free solution-an optimization and comparative study”, Frontiers in Biotechnology, DOI: 10.3389/fbioe.2020.00001.
Pi CH*, Hornberger K*, Dosa PI, Hubel A, "Understanding the frreezing responses of T-cells and other subsets of human peripheral blood mononuclear cells using DSMO-free cryoprotectants, Cytotherapy," 22(5): 291-300, 2020.
Hornberger K, Li R, Duarte ARC, Hubel A, “Natural Deep Eutectic systems for nature-inspired preservation of cells”, AICHE J, DOI: 10.1002/aic.17085.
Li R, Johnson R, Yu G, McKenna DH, Hubel A, “Preservation of cell-based immunotherapies for clinical trials”, Cytotherapy, 21(9): 943-957, 2019.