Ph.D. 1989, Mechanical Engineering, Massachusetts Institute of Technology
M.S. 1989, Mechanical Engineering, Massachusetts Institute of Technology
B.S. 1983 Mechanical Engineering, Iowa State University
Scientific & Professional Societies
Society for Cryobiology
American Society for Mechanical Engineers (ASME)
International Society for Cell Therapy
International Society for Biological and Environmental Repositories
American Institute for Medical and Biological Engineers
Allison Hubel combines her interest in heat and mass transfer, material science and biology to address issues related to preservation of cells and tissues for therapeutic applications. She uses imaging techniques to detect cell response to freezing, optimization algorithms to improve preservation outcome and a variety of other tools to understand the behavior of water during freezing and molecular mechanisms of protection.
Pollock K, Samsonraj RM, Dudakovic A, Thaler R, Stumbras A, McKenna DH, Dosa PI, van Wijnen AJ, Hubel A, “Improved post-thaw function and epigenetic changes in mesenchymal stromal cells cryopreserved using multicomponent osmolyte solutions,” Stem Cells and Development, 26: 828-842, 2017.
Yu G, Pollock K, Yap YR, Hubel A, “Characterizing intracellular ice formation of lymphoblasts cryopreserved in different cryoprotectant compositions using low temperature Raman microspectroscopy,” Biophysical J, 112 (12): 2653-2663, 2017.
Pi C.H., Yu G, Petersen A, Hubel A, “Characterizing the ‘Sweet spot” for the preservation of a T-cell line using osmolytes”, Scientific Reports, 8(1): p. 16223, 2018.
Yu G, Li R, Hubel A, “Interfacial interactions of sucrose during cryopreservation detected by Raman spectroscopy”, Langmuir, DOI: 10.1021/acs.langmuir.8b01616, 2018.