Microfluidics and transport in microfluidic channels
Allison Hubel combines her interest in heat and mass transfer, material science and biology to address issues related to preservation of cells and tissues for therapeutic applications. She uses imaging techniques to detect cell response to freezing, optimization algorithms to improve preservation outcome and a variety of other tools to understand the behavior of water during freezing and molecular mechanisms of protection.
Ph.D. 1989, Mechanical Engineering, Massachusetts Institute of Technology M.S. 1989, Mechanical Engineering, Massachusetts Institute of Technology B.S. 1983 Mechanical Engineering, Iowa State UniversitySociety for Cryobiology
Scientific & Professional Societies
Society for Cryobiology
American Society for Mechanical Engineers (ASME)
International Society for Cell Therapy
International Society for Biological and Environmental Repositories
American Institute for Medical and Biological Engineers
ME 3331: Thermal Sciences I
ME 3333: Thermal Sciences III
ME 4031: Basic Mechanical Measurements Laboratory
ME 4331: Thermal Energy Engineering Laboratory
ME 5666: Modern Thermodynamics
Publications & Awards
Honors and Awards
2017 Outstanding Achievement in Biobanking, ISBER
2013 Scholar, National Blood Foundation
2012 Fellow, American Institute of Medical and Biological Engineers
2008 Fellow, American Society of Mechanical Engineers
2001 Presidential Distinguished Faculty
Pi CH, Dosa PI, Hubel A, “Differential evolution for the optimization of the DMSO-free cryoprotectants: influences of control parameters, J Biomech Engr, 142 (7): 071006.
Li R, Hornberger K, Dutton JR, Hubel A, “Cryopreservation of human iPS cell aggregates in a DMSO-free solution-an optimization and comparative study”, Frontiers in Biotechnology,DOI: 10.3389/fbioe.2020.00001.
Pi CH*, Hornberger K*, Dosa PI, Hubel A, "Understanding the frreezing responses of T-cells and other subsets of human peripheral blood mononuclear cells using DSMO-free cryoprotectants, Cytotherapy," 22(5): 291-300, 2020.
Hornberger K, Li R, Duarte ARC, Hubel A, “Natural Deep Eutectic systems for nature-inspired preservation of cells”, AICHE J, DOI: 10.1002/aic.17085.
Li R, Johnson R, Yu G, McKenna DH, Hubel A, “Preservation of cell-based immunotherapies for clinical trials”, Cytotherapy, 21(9): 943-957, 2019.