Allison Hubel

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Allison Hubel

Professor, Mechanical Engineering


Mechanical Engineering
Room 2101C
111 Church Street SE
Minneapolis, MN 55455


Director, BioCor

Ph.D. 1989, Mechanical Engineering, Massachusetts Institute of Technology
M.S. 1989, Mechanical Engineering, Massachusetts Institute of Technology
B.S. 1983 Mechanical Engineering, Iowa State University

Scientific & Professional Societies
Society for Cryobiology
American Society for Mechanical Engineers (ASME)
International Society for Cell Therapy
International Society for Biological and Environmental Repositories
American Institute for Medical and Biological Engineers

Allison Hubel combines her interest in heat and mass transfer, material science and biology to address issues related to preservation of cells and tissues for therapeutic applications.  She uses imaging techniques to detect cell response to freezing, optimization algorithms to improve preservation outcome and a variety of other tools to understand the behavior of water during freezing and molecular mechanisms of protection.  

BioCor - Biopreservation Core Research - ME 3134
Hubel Research Group

ME Research Areas
Biosystems & Bioengineering
Thermodynamics & Heat Transfer

ME Impact Areas
Human Health
Advanced Manufacturing

Research Interests
  • Molecular mechanisms of damage during freezing
  • Mechanisms of cryoprotection or cryoinjury
  • Low temperature imaging of biological systems
  • Preservation of cells and tissues
  • Microfluidics and transport in microfluidic channels
Teaching Subjects
ME 3331: Thermal Sciences I
ME 3333: Thermal Sciences III
ME 4031: Basic Mechanical Measurements Laboratory
ME 4331: Thermal Energy Engineering Laboratory
ME 5666: Modern Thermodynamics
Honors and Awards
  • 2017 Outstanding Achievement in Biobanking, ISBER
  • 2013 Scholar, National Blood Foundation
  • 2012 Fellow, American Institute of Medical and Biological Engineers
  • 2008 Fellow, American Society of Mechanical Engineers
  • 2001 Presidential Distinguished Faculty
Selected Publications
  • Pollock K, Budenske JW, McKenna DH, Dosa PI, Hubel A, “Algorithm-driven optimization of cryopreservation protocols,” J Tissue Engr Regen Med, 10: 2806-2815, 2017
  • Pollock K, Samsonraj RM, Dudakovic A, Thaler R, Stumbras A, McKenna DH, Dosa PI, van Wijnen AJ, Hubel A, “Improved post-thaw function and epigenetic changes in mesenchymal stromal cells cryopreserved using multicomponent osmolyte solutions,” Stem Cells and Development, 26: 828-842, 2017.
  • Yu G, Pollock K, Yap YR, Hubel A, “Characterizing intracellular ice formation of lymphoblasts cryopreserved in different cryoprotectant compositions using low temperature Raman microspectroscopy,” Biophysical J, 112 (12): 2653-2663, 2017.
  • Pi C.H., Yu G, Petersen A, Hubel A, “Characterizing the ‘Sweet spot” for the preservation of a T-cell line using osmolytes”, Scientific Reports, 8(1): p. 16223, 2018.
  • Yu G, Li R, Hubel A, “Interfacial interactions of sucrose during cryopreservation detected by Raman spectroscopy”, Langmuir, DOI: 10.1021/acs.langmuir.8b01616, 2018.

More Publications

Google Scholar Profile