Professor Tithof's research utilizes a combination of complementary laboratory experiments and numerical simulations to probe important questions at the forefront of fluid mechanics. One area of focus concerns the glymphatic system, which is an important waste clearance pathway in the brain relevant to many neurological disorders, including Alzheimer's disease. His group also explores new approaches to describing fluid flows with the goal of developing reduced-order models, obtaining new insights, and improving forecasting.
Glymphatic system (a waste clearance pathway in the brain involving cerebrospinal fluid flow)
Computational fluid mechanics
Microfluidics and in vitro models
Dynamical systems approaches to turbulence (exact coherent structures, Lagrangian coherent structures)
Machine learning and data-driven modeling
Topological data analysis
Jeff Tithof is an accomplished fluid mechanics researcher and enthusiastic teacher. He particularly enjoys collaboration to solve interdisciplinary problems, utilizing both experimental and numerical approaches.
ME Impact Areas Energy Transition Environment & Sustainability Human Health
Ph.D. 2016, Physics, Georgia Institute of Technology B.S. 2010, Physics & Mathematics, University of Tennessee
Benjamin Mayhugh Assistant Professor, Mechanical Engineering, University of Minnesota, 2020-present Assistant Professor (Research), Mechanical Engineering, University of Rochester, 2019-2020 Postdoctoral Associate, Mechanical Engineering, University of Rochester, 2016-2019
Scientific & Professional Societies
American Association for the Advancement of Science (AAAS)
American Physical Society (APS)
American Society of Mechanical Engineers (ASME)
ME 5351: Computational Heat Transfer
ME 3332: Fluid Mechanics
Publications & Awards
Honors and Awards
Burroughs Wellcome Fund Career Award at the Scientific Interface (2019)
1st Place Video, University of Rochester Art of Science Competition (2018)
University of Rochester Steadman Prize in Interdisciplinary Research (2017)
H. Mestre, T. Du, A. M. Sweeney, G. Liu, A. J. Samson, W. Peng, K. N. Mortensen, F. F. Stæger, P. A. R. Bork, L. Bashford, E. R. Toro, J. Tithof, D. H. Kelley, P. G. Hjorth, E. A. Martens, R. I. Mehta, O. Solis, P. Blinder, D. Kleinfeld, H. Hirase, Y. Mori, M. Nedergaard. “Cerebrospinal fluid influx drives acute ischemic tissue swelling.” Science 367 (2020).
J. Tithof, D. H. Kelley, H. Mestre, M. Nedergaard, and J. H. Thomas. “Hydraulic resistance of periarterial spaces in the brain.” Fluids Barriers CNS 16 (2019): 19.
H. Mestre, J. Tithof, T. Du, W. Song, W. Peng, A. M. Sweeney, G. Olveda, J. H. Thomas, M. Nedergaard, and D. H. Kelley. “Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension.” Nature Commun. 9 (2018): 1-9.
J. Tithof, B. Suri, R. K. Pallantla, R. O. Grigoriev, and M. F. Schatz. “Bifurcations in a quasi-two-dimensional Kolmogorov-like flow.” J. Fluid Mech. 828 (2017): 837–866.
B. Suri, J. Tithof, R. O. Grigoriev, and M. F. Schatz. “Forecasting Fluid Flows Using the Geometry of Turbulence.” Phys. Rev. Lett. 118 (2017): 114501.