Dane Wittrup Seminar (Fredrickson Lecture)

Professor of Chemical Engineering and Biological Engineering at MIT Dr. Dane Wittrup, will deliver this year's Fredrickson Lecture, titled, “Occam’s Pharmacokinetics: Intratumoral Administration and Anchoring,” Tuesday, April 22nd at 1:25 p.m. in room B75 Amundson Hall. 
 
Abstract

On-target, off-tumor toxicity severely limits systemic dosing of cytokines and agonist antibodies for cancer. Intratumoral administration is increasingly being explored to mitigate this problem. Full exploitation of this mode of administration must include a mechanism for sustained retention of the drug; otherwise, rapid diffusion out of the tumor eliminates any advantage. We will present recent work from our lab developing new molecules and design principles for such intratumoral immune therapeutics.

 
Dr. Dane Wittrup Biography

Dr. Wittrup is the C.P. Dubbs Professor of Chemical Engineering and Biological Engineering at MIT. In 2012, he was elected to the National Academy of Engineering. He was also elected a Fellow of the American Association for the Advancement of Science in 2011. Dr. Wittrup is a fellow of the American Institute of Biomedical Engineers. He served as an Associate Director of MIT’s Koch Institute until 2017. He has also served as the J. W. Westwater Professor of Chemical Engineering, Biophysics, and Bioengineering at the University of Illinois at Urbana-Champaign. He previously worked as a postdoctoral research associate in Amgen’s Yeast Molecular Biology Group. He holds a PhD and MS in chemical engineering from the California Institute of Technology and a BS in chemical engineering from the University of New Mexico. Dr. Wittrup is co-founder and acting Chief Scientific Officer at Adimab.