Our group studies regulation of cellular function by the healthy and diseased microenvironment. In particular, we focus on cell-cell interactions, drug delivery, and design of biomaterials for applications in molecular and cellular therapeutics and human disease modeling. Areas of interest include mechanisms of tumor progression and the development of novel treatments for metastatic cancer, molecular transport across physiological barriers, stem cell-derived models of healthy and diseased tissues, and biomanufacturing technologies for emerging cell-based immune therapies. Throughout these efforts, we integrate quantitative analysis of biological processes with tissue engineering approaches and novel biomaterial platforms.
- McKnight Presidential Fellowship, 2021
- George W. Taylor Career Development Award, 2021
- NSF CAREER Award, 2019
- Lee HR, Kim DW, Jones V, Choi Y, Ferry VE, Geller MA, and SM Azarin. "Sonosensitizer-functionalized graphene nano ribbons for adhesion blocking and sonodynamic ablation of ovarian cancer spheroids." Adv Healthcare Mater. 10:e2001368.
- Motallebnejad P and SM Azarin. "Chemically defined human vascular laminins for biologically relevant culture of hiPSC-derived brain microvascular endothelial cells." Fluids Barriers CNS. 17:54.
- Lam T, Aguirre-Ghiso J, Geller MA, Aksan A, and SM Azarin. "Immobilization rapidly selects for chemoresistant ovarian cancer cells with enhanced ability to enter dormancy.” Biotechnol Bioeng. 117:3066-3080.
- Motallebnejad P, Thomas A, Swisher SL, and SM Azarin. "An isogenic hiPSC-derived BBB-on-a-chip." Biomicrofluidics. 13:064119.
- Caronia J, Sorensen D, Leslie H, van Berlo J, and SM Azarin. "Adhesive thermosensitive gels for local delivery of viral vectors." Biotechnol Bioeng. 116:2353-2363.
- Lee HR, Pelaez F, Silbaugh AM, Leslie F, Racila E, and SM Azarin. "Biomaterial platform to establish a hypoxic metastatic niche in vivo." ACS Appl Bio Mater. 2:1549-1560.
- Lee CAA*, Seo HS*, Armien A, Bates FS, Tolar J, and SM Azarin. “Modeling and rescue of defective blood-brain barrier function of induced brain microvascular endothelial cells from childhood cerebral adrenoleukodystrophy patients.” Fluids Barriers CNS. 15:9. *Equal contributions
- Pelaez F*, Manuchehrabadi N*, Roy P, Natesan H, Wang Y, Racila E, Silbaugh AM, Fong H, Zeng K, Bischof JC, and SM Azarin. "Biomaterial scaffolds for non-invasive focal hyperthermia as a potential tool to ablate metastatic cancer cells." Biomaterials. 166:27-37. *Equal contributions
Office: 283 Amundson Hall
- B.S., Chemical Engineering, Massachusetts Institute of Technology, 2006
- Ph.D., Chemical Engineering, University of Wisconsin-Madison, 2011
- Postdoctoral Fellow, Chemical and Biological Engineering, Northwestern University, 2012-2014