Selected Publications
Lopez-Cruzan M, Sharma R, Tiwari M, Karbach S, Holstein D, Martin CR, Lechleiter JD, Herman B. Caspase-2 resides in the mitochondria and mediates apoptosis directly from the mitochondrial compartment. Cell Death Discov. 2016 Feb 15;2. pii: 16005.
Callaway, D., Riquelme, M., Sharma, R., Lopez-Cruzan, M.,Herman, B., and Jiang, J. Caspase-2 Regulates Osteoclastogenesis through Downregulation of Oxidative Stress Bone. 2015 Jul;76:40-8. doi: 10.1016/j.bone.2015.03.006. Epub 2015 Mar 19. Erratum in: Bone. 2016 Dec;93:233-234.
Tiwari M., Sharma L.K., Vanegas D., Callaway D.A., Bai Y., Lechleiter J.D., Herman B. A nonapoptotic role for CASP2/caspase 2: Modulation of autophagy. Autophagy 2014; 10:1054 - 1070; http://dx.doi.org/10.4161/auto.28528
Sharma R, Callaway D, Vanegas D, Bendele M, Lopez-Cruzan M, Horn D, Guda T, Fajardo R, Abboud- Werner S, Herman, B. Caspase-2 maintains bone homeostasis by inducing apoptosis of oxidativelydamaged osteoclasts. PLoS One. 2014 Apr 1;9(4):e93696. doi: 10.1371/journal.pone.0093696. eCollection 2014.
Lopez-Cruzan, M. and Herman, B., Loss of caspase-2 accelerates age-dependent alterations in mitochondrial production of reactive oxygen species. Biogerontology Volume 14, Issue 2, April 2013, Pages 121-130
Klionsky, D. J., Herman, B. et. al., Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 8:4, 1-100; April 2012
Tiwari M, Herman, B, and Morgan W. A knockout of the caspase 2 gene produces increased resistance of the nigrostriatal dopaminergic pathway to MPTP-induced toxicity.(2011) Exp Neurol. Jun;229(2):421-8.
Tiwari, M., Lopez-Cruzan, M., Morgan, W.W., and Herman, B. Loss of caspase-2 dependent apoptosis induces autophagy following mitochondria oxidative stress in primary cultures of young- adult cortical neurons. J. Biol. Chem. published January 7, 2011 as doi:10.1074/jbc.M110.163824