UMN BME-Industry Grand Rounds

Bringing precision medicine to patients with brain diseases

September 12
3:35 - 4:30pm CT

A focused ultrasound platform that opens the blood-brain barrier with a simple, non-invasive 30-minute clinic procedure
Ryan Dittamore, Cordance Medical

Small molecule drug discovery targeting toxic amyloid oligomers for treatment of neurodegeneration
Jonathan Sachs, Department of Biomedical Engineering

New technologies for closed-loop therapy of the nervous system
Company partner: Medtronic

May 9
3:35–4:30pm CT

• Closed-loop spinal cord stimulation using sensed evoked compound action potentials (ECAPs) — Hank Bink, Medtronic
• Tracking physiological signals for improved neurostimulation protocols — Alexander Opitz, Department of Biomedical Engineering
• Methods for closed-loop phase-dependent neurostimulation — Sina Shirinpour, Department of Biomedical Engineering

Better pain therapy by leveraging remote technologies and biomarkers
Company partner: Abbott

April 11
3:35–4:30pm CT

Biomarkers for monitoring efficacy of neuromodulatory treatments for inflammation and pain
Claire Kaiser, Department of Biomedical Engineering

The need for improved pain therapeutics
Tay Netoff, Department of Biomedical Engineering

Digital health in neuromodulation
Yagna Pathak, Abbott

Materials and devices for wound healing and therapeutic delivery 
Company partner: 3M

March 14
3:35–4:30pm CT

CAPRO: A novel biodegradable material for drug delivery
Marcus Flowers, Department of Biomedical Engineering

Materials and devices for wound healing
Kris Kieswetter, 3M
Amy McNulty, 3M

Polymer wafers for noninvasive delivery of protein vaccines
Chun Wang, Department of Biomedical Engineering

Innovations in peripheral venous interventions 
Company partner: Boston Scientific

Feb. 14
3:35–4:30pm CT
 

Varithena: Treating veins with injectable foam
Benjamin Bayder
Sr. Product Manager, Venous Marketing, Boston Scientific

Tissue-engineered transcatheter vein valve
Robert Tranquillo
Distinguished McKnight University Professor, Department of Biomedical Engineering

Bioengineering platforms to understand human disease 
Company partner: Bio-Techne

Jan. 10
3:35–4:30pm CT

• Amanda Alexander, Bio-Techne — Using EllaTM, a microfluidic automated ELISA platform, in neurodegenerative disease research
• Paolo Provenzano, Department of Biomedical Engineering — Stromal disruption and cell engineering strategies to enhance distribution of cytotoxic T cells

The role of photoacoustics, ultrasound, and electromagnetics in image-guided therapies 
Company partner: Medtronic

November 8, 2021
3:35–4:30pm CT

• Joseph Brannan, Medtronic — Medtronic image guided tumor ablation technology
• Shai Ashkenazi, Department of Biomedical Engineering — Photoacoustic technology for sensing and imaging

Clinical applications of neurostimulation 
Company partner: Inspire Medical Systems

Oct. 11, 2021
3:35–4:30pm CT

Speakers

• Kent Lee, Research Fellow, Inspire Medical Systems—How a new neurostimulation therapy for treating obstructive sleep apnea was developed
• Jennifer Hsia, Assistant Professor, Department of Otolaryngology—Physician and patient’s perspective on Inspire therapy experience and programming
• Tay Netoff, Professor, Department of Biomedical Engineering

Enhancing human senses 
Company partner: Starkey

Sept. 13
3:35–4:30pm CT

The human sensory perception system is remarkable, allowing us to sense and understand the world around us almost effortlessly. However, as we age, our sensation, perception, and cognition systems generally degrade. Traumatic injuries from accidents or overexposure to harmful stimulus levels can also result in catastrophic impact to human perceptual processes. Sustained sensory deprivations have been associated with cognitive declines and other comorbidities.

Recent technological advances in sensors and computation, especially breakthroughs in miniaturized hardware components and artificial intelligence algorithms based on modern machine learning techniques, are increasingly enabling the development of various types of assistive devices that can help enhance and augment the human senses. In this lecture, we will review:

• The neuroscience of sensory perception system
• Mechanisms and impacts of common sensory deficiencies
• Recent advances and future trends in perceptual assistive technologies

Speakers

• Achin Bhowmik, PhD, Chief Technology Officer at Starkey and Adjunct Professor at Stanford
• Zhi Yang, PhD, Department of Biomedical Engineering at the University of Minnesota and Fasikl Inc.

Computational models to provide physiologic insights and aid in clinical study design 
Company partner: Medtronic

April 19, 2021
3:35–4:30pm CT

Speakers

• Computational modeling in cardiac implantables at Medtronic—Ruth Nicholson Klepfer, Innovation Director, Cardiac Implantables, Medtronic
• Research examples of the value of computational modeling in medical devices—Troy Jackson, Distinguished Scientist, Cardiac Implantables, Medtronic
• Biophysical modeling for COVID-19 antiviral development—David Odde, Professor, Department of Biomedical Engineering
• Biophysical modeling for cancer cell migration—Sarah Anderson, BME PhD candidate

Developing an AI-based system for improved hemorrhagic stroke treatment: A case study in collaboration 
Company partner: Minnetronix Medical

March 8, 2021
3:35–4:30pm CT

• Pursuing Better Patient Outcomes by Linking Interventions with Decision Support — Aaron McCabe, PhD, Minnetronix Medical
• Interventional Needs enabled by Decision Support in the ICH Population – Andrew Grande, MD, Department of Neurosurgery
• A Collaborative Approach to AI Development – Laura Zitella Verbick, PhD, Minnetronix Medical
• Reflections and Learnings from Collaboration – Kaitlin Kramer, Minnetronix Medical
• BME Curriculum and Student Research Experiences working with Medical Image Processing and AI – Matthew Johnson, PhD, Department of Biomedical Engineering

Microfluidics in bioengineering: Small tools with big impacts 
Company partner: Bio-Techne

Feb. 8, 2021
3:35–4:30pm CT

• Intro — Dave Wood, Associate Professor, Department of Biomedical Engineering
• A microfluidics-based, automated ELISA platform: Next generation immunoassays for better precision and reproducibility — Yoav Noam, Scientist and Supervisor, Bio-Techne
• Tissue engineering on a chip — Lizzy Crist, PhD Candidate, Department of Biomedical Engineering
• Microfluidics for synthesis and manufacturing — Ali Crampton, Researcher, Department of Biomedical Engineering