Ismail Guler is an R&D Fellow at Boston Scientific Corporation in Maple Grove, Minnesota, where he has applied computational modeling and simulation since 1998 to support the development of life-improving and life-saving medical devices and therapies. Prior to joining Boston Scientific, he was a member of the Team for Advanced Flow Simulation and Modeling at the Army High Performance Computing Research Center in Minneapolis. He is a member of the ASME VVUQ 40 Subcommittee, which developed the international standard “Assessing Credibility of Computational Modeling through Verification and Validation: Application to Medical Devices.” He has led a working group on calculation verification, contributed to a working group on code verification, and serves on an ASME task group focused on verification, validation, and uncertainty quantification (VVUQ) concepts in engineering education.

Education

• BS, Mechanical Engineering, Boğaziçi University, Turkey, 1993
• MS, Mechanical Engineering, Boğaziçi University, Turkey, 1995
• MS, Aerospace Engineering, University of Minnesota, 1997

Teaching Subjects

• BMEN 4015 – Computational Modeling of Biomechanical & Biotransport Devices

Honors and Awards

• Patent Milestone Award (10-14 Patents), Boston Scientific Corporation, 2022
• CEO Winning Spirit Award, Boston Scientific Corporation, 2020
• KDPD Leadership Award, Boston Scientific Corporation, 2020
• ImagineIF Innovation Fund Award, Boston Scientific Corporation, 2016
• John Abele Science & Technology Award, Boston Scientific Corporation, 2015

Selected Publications

Craven BA, et al., “Computational modeling and simulation for medical devices: a summary of the 2024 FDA/MDIC Symposium”, Progress in Biomedical Engineering, vol. 8, 013001, 2026.

Guler I, Aycock KI, and Rebelo N, “Two calculation verification metrics used in the medical device industry: Revisiting the limitations of fractional change”, ASME Journal of Verification, Validation, and Uncertainty Quantification, vol. 7(3), 031004, 2022.

Barocas V, Drasler W, Girton T, Guler I, Knapp D, Moeller J and Parsonage E, “A dissolution diffusion model for TAXUS drug-eluting stent with surface burst estimated from continuum percolation”, Journal of Biomedical Materials Research: Part B - Applied Biomaterials, vol. 90B, 267-274, 2009.

Srianni RW, Kremer J, Guler I, Chen YL, Keeley FW and Saltzman WM, “Effect of extracellular matrix elements on the transport of Paclitaxel through an arterial wall tissue mimic”, Biomacromolecules, vol. 9, 2792-2798, 2008.

LaDisa JF Jr, Olson LE, Guler I, Hettrick DA, Audi SH, Kersten JR, Warltier DC and Pagel PS, “Circumferential vascular deformation after stent implantation alters wall shear stress evaluated with time-dependent 3D computational fluid dynamics models”, Journal of Applied Physiology, vol. 98, 947-957, 2005.  

LaDisa JF Jr, Olson LE, Guler I, Hettrick DA, Audi SH, Kersten JR, Warltier DC and Pagel PS, “Stent design properties and deployment ratio influence indexes of wall shear stress: a three-dimensional computational fluid dynamics investigation within a normal artery”, Journal of Applied Physiology, vol. 97, 424-430, 2004.

LaDisa JF Jr, Guler I, Olson LE, Hettrick DA, Kersten JR, Warltier DC and Pagel PS, “Three-dimensional computational fluid dynamics modeling of alterations in coronary wall shear stress produced by stent implantation”, Annals of Biomedical Engineering, vol. 31, 972-980, 2003.

LaDisa JF Jr, Hettrick DA, Olson LE, Guler I, E.R. Gross ER, Kress TT, Kersten JR, Warltier DC and Pagel PS, “Stent implantation alters coronary artery hemodynamics and wall shear stress during maximal vasodilation”, Journal of Applied Physiology, vol. 93, 1939-1946, 2002.

Guler I, Behr M and Tezduyar T, “Parallel finite element computation of free-surface flows”, Computational Mechanics, vol.23, 117-123, 1999.