The Cannon Lab develops innovative optical imaging techniques to capture how disruptions in central and peripheral nervous system dynamics drive disorder and disease throughout the body. Brain-body communication is critical for coordinating local function in specific organs with multi-system demands, but the scope, versatility, and transient nature of these interactions make them difficult to characterize. By engineering new tools for optical imaging deep within the body, we make it possible to visualize and quantify cellular signaling events with molecular detail. Our work spans the design and fabrication of custom imaging devices, chronic data collection in vivo, and the development of signal processing algorithms tailored to specific applications. The insights gained from being able to see the body’s internal communication in new ways aid in furthering our mechanistic understanding of disease progression, empowering new diagnostic tools, and supporting the creation and optimization of targeted therapeutics.

Research Tags:

Education

• B.S., Biomedical Engineering, Vanderbilt University, 2016
• Ph.D., Medical Engineering and Medical Physics, Massachusetts Institute of Technology, 2023

Selected Publications

Nicolette Driscoll,* Marc-Joseph Antonini,* Taylor M Cannon,* Pema Maretich,* Greatness Olaitan, Valerie Doan Phi Van, Keisuke Nagao, Atharva Sahasrabudhe, Emmanuel Vargas Paniagua, Ethan J Frey, Ye Ji Kim, Sydney Hunt, Melissa Hummel, Sanju Mupparaju, Alan Jasanoff, B Jill Venton, Polina Anikeeva. Multifunctional Neural Probes Enable Bidirectional Electrical, Optical, and Chemical Recording and Stimulation In Vivo. Advanced Materials 37(49), 2024.

Taylor M Cannon, Brett E Bouma, Nestor Uribe-Patarroyo. Mapping optical scattering properties to physical particle information in singly and multiply scattering samples. Biomedical Optics Express 14(8), 2023.

Taylor M Cannon, Nestor Uribe-Patarroyo, Martin Villiger, Brett E Bouma. Measuring collagen injury depth for burn severity determination using polarization sensitive optical coherence tomography. Scientific Reports 12(1), 2022.

Taylor M Cannon, Nestor Uribe-Patarroyo, Brett E Bouma. Layer-based, depth-resolved computation of attenuation coefficients and backscattering fractions in tissue using optical coherence tomography. Biomedical Optics Express 12(8), 2021.

Taylor M Cannon, Joao L Lagarto, Benjamin T Dyer, Edwin Garcia, Douglas J Kelly, Nicholas S Peters, Alexander R Lyon, Paul MW French, Chris Dunsby. Characterization of NADH fluorescence properties under one-photon excitation with respect to temperature, pH, and binding to lactate dehydrogenase. OSA Continuum 4(5), 2021.

Taylor M Cannon, Amy T Shah, Melissa C Skala. Autofluorescence imaging captures heterogeneous drug response differences between 2D and 3D breast cancer cultures. Biomedical Optics Express 8(3), 2017.

Taylor M Cannon, Amy T Shah, Alex J Walsh, Melissa C Skala. High-throughput measurements of the optical redox ratio using a commercial microplate reader. Journal of Biomedical Optics 20(1), 2015.