Professor Adrian Whitty

Associate Professor
Department of Chemistry
Boston University
Printable Abstract

Design Principles for Growth Factor Receptors

Cytokine and growth factor receptors display a variety of subunit compositions and architectures, and fill a wide range of biological roles regulating diverse aspects of cellular function. Our quantitative understanding of their mechanism(s) of action lags far behind what we know about comparably important protein classes such as enzymes, GPCRs, and ion channels, however. I will describe our work on the activation mechanism of the receptor tyrosine kinase RET, and what it reveals about how specific mechanistic features relate to the sensitivity, amplitude, and dynamic regulation of the signaling response.

Hosted by Professor Rick Wagner

For more information and schedule: https://cbitg.chem.umn.edu/chemical-biology-initiative/cbi-seminar-schedule