Professor Michelle Arkin
Professor and Department Chair Michelle Arkin
Department of Pharmaceutical Chemistry
University of California San Francisco
Host: Professor Ambika Bhagi-Damodaran
Site-directed drug discovery
Michelle Arkin’s lab develops methods and molecules to target currently ‘undruggable targets’ like proteases and protein-protein interactions. This presentation will describe how the lab uses a fragment-based approach called disulfide tethering to discover chemical probes with new mechanisms of action for these two protein classes. Michelle also co-Directs the UCSF Small Molecule Discovery Center, which collaborates on chemical biology and drug discovery research.
Michelle Arkin
Michelle Arkin is professor and chair of Department of Pharmaceutical Chemistry at the University of California, San Francisco. Michelle’s lab develops innovative approaches to screen for chemical tools and drug leads, using biophysical approaches like fragment-based drug discovery and biological approaches including high-content imaging with primary cells and organisms. Michelle is co-Director of the Small Molecule Discovery Center, a collaborative research and core lab that includes a high-throughput screening facility and medicinal chemistry.