Professor Bobby Arora

Professor Bobby Arora
Department of Chemistry
NYU

Short stories in molecular recognition (of protein surfaces) and catalysis (of amide bonds)

Protein-protein complexes are difficult targets for inhibitor design, and therefore, offer a testing ground for new approaches. We are developing a rational design approach that begins by mimicry of protein interfaces by constrained peptides and peptidomimetics. The first part of this presentation will discuss the application of our approach to the discovery of inhibitors for oncogenic targets Ras and, the intrinsically disordered, Myc. The second part of the talk will focus on a rational design approach to develop catalysts for peptide bond formation. This work aims to address the significant challenge of excess reagent use in peptide synthesis.

Paramjit Arora

Paramjit Arora is a Professor of Chemistry at New York University. He obtained his B.S. and Ph.D. in Chemistry from UC Berkeley and UC Irvine, respectively. He was an American Cancer Society postdoctoral fellow at the California Institute of Technology before joining the faculty of New York University. His research focuses on designer protein mimics that modulate biomolecular interactions.

Hosted by Professor William Pomerantz