Professor Yutaka Miura

Professor Yutaka Miura

Tokyo Institute of Technology

Abstract

“Multifunctional Nanoassemblies of Synthetic Polymers for Future Therapy and Diagnosis”

Polymeric micelles are demonstrating high potential as nanomedicines capable of controlling the distribution and function of loaded bioactive agents in the body, effectively overcoming biological barriers, and various formulations are engaged in intensive preclinical and clinical testing. Here we focus on polymeric micelles assembled through multimolecular interactions between block copolymers and the loaded drugs as translationable nanomedicines. The aspects involved in the design of successful micellar carriers are explained in detail on the basis of the type of polymer/payload interaction, as well as the interplay of micelles with the biological interface, emphasizing the importance of the chemistry and engineering of the polymers.