Lawrence "Larry" Que Jr.

portrait of Professor Lawrence Que Jr

Lawrence "Larry" Que Jr.

Regents Professor, Distinguished University Teaching Professor, Department of Chemistry

Contact

Smith Hall
Room 343
207 Pleasant Street Se
Minneapolis, MN 55455

Affiliations

Center for Metals in Biocatalysis
Chemistry-Biology Interface Training Grant
Education

B.S. Ateneo de Manila University, 1969 

Ph.D. University of Minnesota, 1973 (Louis H. Pignolet)

Post Doctorate Massachusetts Institutes of Technology (Richard H. Holm), University of Minnesota (Eckard Münck), 1973-1977

Research Interests

Inorganic & Organometallic Chemistry: bioinorganic chemistry

Chemical Biology: nonheme iron enzymes

Environmental & Green Chemistry: enzymatic oxidation

Energy & Catalysis

Our group focuses on bio-inorganic chemistry, specifically on the topic of iron, oxygen and (bio)catalysis. Our research effort, involving a combination of biochemical, synthetic inorganic, and spectroscopic approaches, is aimed at elucidating the oxygen activation mechanisms of nonheme iron enzymes, designing functional models for such enzymes, trapping and characterizing reaction intermediates, and developing bio-inspired oxidation catalysts for green chemistry applications. The pictures illustrate the crystal structure of a recently isolated oxoiron(IV) complex with the oxo atom syn to the methyl groups of the TMC macrocycle and a DFT-calculated structure for a reactive intermediate that we have trapped in our efforts to develop bio-inspired iron catalysts for hydrocarbon oxidation.

 crystal structure of a oxoiron(IV) complex with the oxo atom syn to the methyl groups of the TMC macrocycle
Crystal structure of an isolated oxoiron(IV) complex with the oxo atom syn to the methyl groups of the TMC macrocycle.
DFT-calculated structure for a reactive intermediate trapped to develop bio-inspired iron catalysts for hydrocarbon oxidation
DFT-calculated structure for a reactive intermediate trapped to develop bio-inspired iron catalysts for hydrocarbon oxidation.
Honors and Awards

American Chemical Society Award in Inorganic Chemistry, 2017

Japan Society of Coordination Chemistry International Award, 2015

John C. Bailar Jr. Medal from University of Illinois Urbana-Champaign, 2012

Elected American Chemical Society Fellow, 2011

Royal Society of Chemistry Inorganic Reaction Mechanisms Award, 2011

Designated Fellow of the Royal Society of Chemistry, 2008

American Chemical Society Alfred Bader Award in Bioinorganic or Bioorganic Chemistry, 2008

Frontiers in Biological Chemistry Award from the Max-Planck-Institut für Bioanorganishe Chemie, 2005

Elected Fellow of the American Association for the Advancement of Science, 2001

National Institutes of Health MERIT Award, 2000-2010

University of Minnesota Award for Outstanding Contributions in Post-Baccalaureate, Graduate, and Professional Education, 1999-2000

National Institutes of Health Research Career Development Award, 1982-1987

Alfred P. Sloan Research Fellowship, 1982-1986

Mailing Address

Lawrence Que
University of Minnesota
Department of Chemistry
B-16, 139 Smith Hall, 207 Pleasant St SE
Minneapolis, MN 55455-0431