- Analytical & Bioanalytical Chemistry: separations, microfluidics, microdialysis, aptamers
- Chemical Biology: obesity, heart disease, exobiology, nucleic acids
Research Summary
The focus of Professor Bowser's group is to advance bioanalytical technologies used to study problems of biological and medical importance. Technologies of expertise include high-speed microdialysis assays, aptamers and microfluidics. Major contributions made by the Bowser group include:
- the development of microfluidic strategies for isolating aptamers (i.e. CE-SELEX);
- the design and characterization of microscale free flow electrophoresis (µFFE) devices for high-speed monitoring and microscale purification; and
- the introduction of in vitromicrodialysis, a technique that allows high-speed measurements of chemical release/uptake in cellular systems.
Applications of particular interest include adipocyte signaling in obesity, modulation of heart function using short, protein interacting oligonucleotides, aptamers that facilitate cell delivery or catalyze reactions, and high-speed multidimensional separations.
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