Seven graduate students honored with Doctoral Dissertation Fellowships

MINNEAPOLIS / ST. PAUL (7/18/2024) – Seven graduate students advised by Department of Chemistry faculty members were recently awarded the University of Minnesota’s Doctoral Dissertation Fellowship. The seven students honored by this prestigious award are Kaylee Barr, Brylon Denman, Madeline Honig, Chris Seong, Sneha Venkatachalapathy, Murphi Williams, and Caini Zheng.

Kaylee Barr, a Chemical Engineering and Materials Science PhD student, is entering her fifth year in the Reineke Group. Before making the move to Minnesota, she received her BS in Chemical Engineering from the University of Kansas. “I came to the University of Minnesota because of the department's developments in polymer science, and because I was interested in the intersection of polymer science and drug delivery in Theresa Reineke's lab,” she says. Here at UMN, Kaylee studies how bottlebrush polymer architecture affects pH-responsive oral drug delivery. This summer, she is excited to grow professionally and as a scientist in an intern position at Genentech.

Brylon Denman is a Chemistry PhD candidate in the Roberts Group. She joined the UMN community in 2020 after completing her BS in Biochemistry at St. Louis University. “My research in the Roberts group seeks to resolve regioselectivity and reactivity issues within aryne methodology via ligand control,” Brylon says. “To accomplish this task, I have taken a mechanistic and hypothesis driven approach to understand how key molecular parameters modify regioselectivity and reactivity. I hope to use the knowledge I have gained from these studies to both improve the synthetic utility of aryne intermediates, and improve the sustainability of aryne reactions.” Brylon is also passionate about sustainable and green chemistry. As a founding member of the Sustainable and Green Chemistry committee, Brylon strives to collaborate with other department teammates to strengthen the culture of green and sustainable chemistry through integration into teaching, research, and community engagement. “In my career I aim to continue this advocacy and use my breadth of knowledge to enact sustainable change at a major pharmaceutical company as emphasizing sustainability on such a large scale can lead to a large impact,” she says. As she works through her internship at AbbVie this summer, Brylon is looking towards the future to outline her next steps after graduation.

Madeline Honig first experienced Chemistry at UMN during a summer REU experience in the Bühlmann Lab. She formally joined the Prof. Bühlmann's team in Fall 2020 after earning her BA in Chemistry from Earlham College. Her research here at UMN  has focused on the development and improved understanding of polymeric membrane-based ion-selective electrodes (ISEs). “One of my projects involves developing a quantitative parameter to better define the upper detection limits of these sensors which can be used to more accurately define sensor performance and predict the working range under different conditions,” Madeline says. “This research led us to investigate the unexplained 'super-Nernstian' responses of some pH-selective electrodes and expand the phase boundary model (the quantitative model that predicts ISE behavior) to include the formation of complexes between protonated ionophores and counter-ions in the sensing membrane. ISEs have been widely used for decades in clinical blood analysis among many other applications so it's exciting that I was still able to add to our fundamental understanding of how these sensors function.” One of Madeline’s goals is to use her research to enable the development of improved sensors that can be used in a wider range of conditions. Over the course of her graduate studies, Madeline has had the opportunity to be a graduate student mentor for two other students: Ariki Haba, a visiting master's student from Japan, and Katie O'Leary, a summer REU student, who both made significant contributions to the project. “Acting as a graduate mentor was really cool and I hope I can also make graduate-level chemistry research more approachable for everyone that I work with,” Madeline says. For her significant research efforts, Madeline was also recently selected in a national competition as one of the four winners of the 2024 Eastern Analytical Symposium Graduate Student Research Award. She will accept the award in November in Plainsboro NJ at the Eastern Analytical Symposium.

Chris Seong, an international student from New Zealand and PhD candidate in the Roberts Group, came to UMN after completing his BA with Distinction in Chemistry at St. Olaf College in 2020. Chris’ overarching chemistry interests involve the development of methods to utilize naturally abundant carboxylic acids as feedstock to synthesize medicinally relevant products, which are traditionally made with non-renewable starting materials derived from fossil fuels. “My earlier work has been focused on making alkyl-alkyl bonds through decarboxylation, but lately, in true Roberts Group fashion, I have turned my attention to using a similar mechanism to do aryne chemistry,” Chris says. He is currently working to publish a paper on the aryne project that he has been working on with two talented group mates; Sal Kargbo and Felicia Yu. “I am really excited to share this cool chemistry with the world,” he says. Outside of the lab, Chris is working on expanding his network to apply for jobs in the pharmaceutical industry – specifically in the early process space.

Sneha Venkatachalapathy is a member of the Distefano Group and an international student from India. She completed her BS in Chemistry with a minor degree in Biotechnology from Shiv Nadar University, Greater Noida, India in 2020. “Chemistry has always been my passion since high school. I still remember my first successful brown ring test that has left a remarkable fascination and interest towards chemistry,” Sneha says. “This early fascination has driven my academic journey, guided by mentors like Dr. Subhabrata Sen, who encouraged me to pursue a PhD in the United States.” Sneha was drawn towards working in the Chemical Biology research field where she could directly contribute to developing human life. “Joining Dr. Mark Distefano’s lab at UMN provided me with the chance to collaborate with Dr. Mohammad Rashidian from Dana Farber Cancer Institute. Together, we work towards expanding the scope of protein prenylation to construct protein-based cancer diagnostic tools,” she says. Sneha’s goal for her time in the UMN PhD program is to create innovative protein-based tools for cancer detection and treatment, aiming to enhance patient’s quality of life. She says she is looking forward to continuing to develop her leadership skills as she continues her doctorate, and is also exploring future opportunities beyond UMN. “One thing that motivates me daily is the belief that my research contributions to the scientific community would enhance our understanding of cancer diagnostic methods, ultimately leading to improved patient outcomes worldwide,” she says.

Murphi Williams completed her undergraduate studies at the University of Wisconsin-Eau Claire, then joined the Bhagi-Damodaran at UMN in 2020. When it comes to research, Murphi is interested in chemical biology, more specifically, looking into proteins involved in important biological problems. “One of my major projects is developing and characterizing a potential inhibitor for Mycobacterium tuberculosis, the bacteria that causes tuberculosis,” Murphi says. “Tuberculosis is the leading infectious disease so my projects center on understanding and inhibiting heme proteins important for the bacteria. Specifically, a previous lab member identified a small molecule that I've been characterizing the activity of in cells.” Her current research goal is to express and purify the protein targets for her small molecule inhibitor in the lab to further demonstrate the in vitro activity. She is also contemplating a future career in science communication. Outside of the lab, she enjoys working on her garden. 

Caini Zheng joined the Chemistry at the UMN in 2019 after finishing her undergraduate studies at Shanghai Jiao Tong University. She is currently a sixth-year graduate student co-advised by Profs. Tim Lodge and Ilja Siepmann. Her research focuses on the phase behavior of soft materials, including polymers and oligomers. Her DDF statement is titled "Self-Assembly of Polymers and Amphiphiles into Bicontinuous Phases". Caini is currently working on a project to elucidate the self-assembly of glycolipids through molecular dynamics simulations coupled with machine learning methods. In the future, she wants to work in the industry on bridging data science with traditional material research.