A large-scale comparative study of isoform expressions measured on four platforms
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Journal

BMC Genomics - March 30, 2020

Authors

Wei Zhang, Raphael Petegrosso (Ph.D. 2019), Jae-Woong Chang, Jiao Sun, Jeongsik Yong, Jeremy Chien, Rui Kuang (associate professor)

Abstract

Most eukaryotic genes produce different transcripts of multiple isoforms by inclusion or exclusion of particular exons. The isoforms of a gene often play diverse functional roles, and thus it is necessary to accurately measure isoform expressions as well as gene expressions. While previous studies have demonstrated the strong agreement between mRNA sequencing (RNA-seq) and array-based gene and/or isoform quantification platforms (Microarray gene expression and Exon-array), the more recently developed NanoString platform has not been systematically evaluated and compared, especially in large-scale studies across different cancer domains.

Link to full paper

A large-scale comparative study of isoform expressions measured on four platforms

Keywords

bioinformatics, computational biology

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